TM Owner Novartis
Lotrel 10mg/40mg Capsule
Global Shipping : Reliable Global Distribution Network
Express Delivery : Priority Shipping for Every Order
Secure Payments : Trusted Payment Protection System
Disclaimer
Secure Handling
24/7 Worldwide Support
Global Access
Worldwide Access to Health
Cold-Chain Expert
Excellence in Cold-Chain
Trusted Supply
Certified Medical Supply
Indications & Clinical Uses
- Lotrel 10 mg/40 mg capsules contain two blood pressure medicines in one capsule: amlodipine, a dihydropyridine calcium channel blocker, and benazepril hydrochloride, an angiotensin-converting enzyme (ACE) inhibitor.
- Lotrel is approved for the treatment of high blood pressure (hypertension) in adults whose blood pressure is not adequately controlled on either medicine alone, or who develop dose-limiting side effects on one of them.
- Lowering blood pressure reduces the risk of cardiovascular events, particularly strokes and heart attacks.
- Lotrel is supplied in several strengths, including 2.5 mg/10 mg, 5 mg/10 mg, 5 mg/20 mg, 10 mg/20 mg and 10 mg/40 mg, so the capsule must always be checked against the prescription.
- Treatment usually starts at 2.5 mg/10 mg once daily and is titrated upwards to a maximum of 10 mg/40 mg once daily according to response; the full effect on blood pressure is generally seen within 2 weeks.
- It is taken by the patient at home.
Side Effects
- Lotrel carries a BOXED WARNING on FETAL TOXICITY: when pregnancy is detected, Lotrel must be stopped as soon as possible, because medicines acting directly on the renin-angiotensin system can injure and kill the developing baby.
- The most common side effects in trials were cough (3.3%), headache (2.2%), ankle or leg swelling (2.1%) and dizziness (1.3%); about 4% of people stopped treatment because of side effects, mainly cough and swelling.
- The cough is dry and persistent and comes from the benazepril component, while the ankle swelling comes mainly from amlodipine.
- Serious reactions to recognise are angioedema - swelling of the face, lips, tongue, throat, limbs or bowel, which is more common in Black patients and can be fatal; severe low blood pressure with fainting; high potassium; worsening kidney function; rarely hepatitis and liver failure; and worsening chest pain or heart attack when starting or increasing the dose in severe coronary artery disease.
- Get emergency help for facial or tongue swelling or trouble breathing.
Precautions & Warnings
- Blood pressure, kidney function and serum potassium should be monitored, especially during the first weeks, after dose increases and in people with kidney disease, diabetes, heart failure or dehydration from diuretics, vomiting or diarrhoea.
- Lotrel is CONTRAINDICATED in anyone with a history of angioedema, including angioedema after any ACE inhibitor, and in people allergic to benazepril or amlodipine.
- Do not use it with a neprilysin inhibitor such as sacubitril/valsartan, and allow a 36-hour gap when switching.
- Do not use it with aliskiren if you have diabetes.
- Lotrel must NOT be used in pregnancy at any stage; tell your healthcare provider immediately if you become pregnant.
- Dizziness and light-headedness are common when starting, so take care when driving or standing up quickly.
- Lower doses are used in kidney or liver impairment and in frail older people.
- Store the capsules at 20°C to 25°C, protect them from moisture and keep them in a tight container.
Avoid Interactions
- Medicines that INCREASE the risk of harm with Lotrel are potassium supplements, potassium-containing salt substitutes and potassium-sparing diuretics such as spironolactone, amiloride, triamterene and eplerenone, which raise potassium; other blood pressure medicines, diuretics and alcohol, which deepen the fall in blood pressure; lithium, whose levels and toxicity rise; angiotensin receptor blockers or aliskiren, because dual renin-angiotensin blockade increases hypotension, hyperkalaemia and kidney failure; mTOR inhibitors such as sirolimus and neprilysin inhibitors, which raise the risk of angioedema; and strong CYP3A inhibitors and grapefruit, which can raise amlodipine levels.
- Amlodipine increases simvastatin exposure, so the simvastatin dose must be limited to 20 mg daily.
- Non-steroidal anti-inflammatory drugs including ibuprofen and COX-2 inhibitors REDUCE the blood pressure-lowering effect and can impair kidney function, particularly in older or dehydrated patients.
- Tell your healthcare provider about every medicine, herbal product and supplement you take.
References
- LOTREL (amlodipine besylate and benazepril hydrochloride) capsules - US Prescribing Information, DailyMed (Novartis Pharmaceuticals Corporation)
- Lotrel - professional prescribing information, Drugs.com
- LOTENSIN (benazepril hydrochloride) tablets - US Prescribing Information, DailyMed (Validus Pharmaceuticals LLC)
Frequently Asked Questions
Lotrel 10 mg/40 mg capsules treat high blood pressure in adults whose blood pressure is not controlled by one medicine alone. Each capsule combines amlodipine, a calcium channel blocker, with benazepril, an ACE inhibitor. Lowering blood pressure reduces the risk of strokes and heart attacks.
Take one Lotrel (amlodipine and benazepril) capsule once daily, with or without food, at about the same time each day. Treatment usually starts at 2.5 mg/10 mg and is increased to a maximum of 10 mg/40 mg. The full blood pressure effect appears within 2 weeks.
The most common Lotrel (amlodipine and benazepril) side effects are dry cough in about 3%, headache in 2%, ankle or leg swelling in 2% and dizziness in 1%. Get emergency help for angioedema - swelling of the face, lips, tongue or throat - which can be fatal.
No. Lotrel (amlodipine and benazepril) has a boxed warning for fetal toxicity: medicines acting on the renin-angiotensin system can injure and kill an unborn baby. Stop Lotrel as soon as pregnancy is detected and tell your healthcare provider immediately if you become pregnant or plan to.
Avoid potassium supplements, potassium salt substitutes and potassium-sparing diuretics with Lotrel (amlodipine and benazepril). Avoid ibuprofen and other NSAIDs, which reduce its effect and can harm the kidneys. Never combine it with sacubitril/valsartan, or with aliskiren if you have diabetes. Limit simvastatin to 20 mg daily.
No. Lotensin contains benazepril only, while Lotrel combines amlodipine with benazepril in one capsule. They are not interchangeable. Lotrel also comes in several strengths, from 2.5 mg/10 mg up to 10 mg/40 mg, so always check the capsule matches your prescription.
Trusted & Reliable – Your Partner in Global Distribution.
We provide comprehensive lines of pharmaceutical products to support all your healthcare distribution needs.
