TM Owner Jazz Pharmaceuticals
Luvox 150mg Capsule
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Indications & Clinical Uses
- Luvox 150 mg here refers to fluvoxamine maleate extended-release capsules, marketed as Luvox CR - the capsule form of fluvoxamine; the original immediate-release Luvox brand is a tablet, not a capsule, so this profile matches Luvox CR specifically.
- Fluvoxamine is a selective serotonin reuptake inhibitor (SSRI).
- Luvox CR is FDA-approved for obsessive-compulsive disorder (OCD) in adults and children aged 8 years and older, and for social anxiety disorder in adults only.
- It is currently marketed in the US by Jazz Pharmaceuticals, Inc.
- Capsules are swallowed whole, once daily at bedtime, and must not be crushed, chewed or opened.
- This medicine carries an FDA boxed warning about increased suicidal thinking and behaviour in children, adolescents and young adults, discussed further below.
Side Effects
- Very common side effects of Luvox CR include nausea, insomnia, drowsiness, dizziness, dry mouth, sweating, tremor, decreased appetite and sexual problems such as abnormal ejaculation or reduced libido.
- Luvox CR carries an FDA boxed warning: antidepressants, including fluvoxamine, increase the risk of suicidal thinking and behaviour in children, adolescents and young adults under 25, especially in the first weeks of treatment or after a dose change, so close monitoring for worsening mood, agitation or unusual behaviour is essential.
- Seek urgent medical help for symptoms of serotonin syndrome (agitation, rapid heartbeat, high fever, muscle rigidity), unusual bleeding, signs of mania, or a seizure.
- Do not stop Luvox CR abruptly, as this can cause withdrawal effects such as anxiety, dizziness and irritability; reduce the dose gradually under medical guidance.
Precautions & Warnings
- Before starting Luvox CR, tell your healthcare provider if you or a family member has bipolar disorder, since antidepressants can trigger a manic episode; screening for bipolar disorder is recommended first.
- Use caution if you have a history of seizures, glaucoma, liver impairment or a bleeding disorder, and if you take other drugs that increase bleeding risk such as NSAIDs, aspirin or warfarin.
- Luvox CR is not approved for use in children under 8, and should be used in pregnancy only if the benefit outweighs the risk, since untreated depression or OCD in pregnancy also carries risks; discuss breastfeeding with your healthcare provider.
- Elderly patients have a higher risk of low sodium levels (hyponatraemia).
- Capsules must be swallowed whole and not crushed, chewed or split.
Avoid Interactions
- Do not take Luvox CR with, or within 14 days of stopping, a monoamine oxidase inhibitor (MAOI), and never combine it with thioridazine, pimozide, tizanidine, alosetron or ramelteon, which are contraindicated.
- Combining Luvox CR with other serotonergic drugs - other antidepressants, triptans, tramadol, lithium or St John's Wort - raises the risk of serotonin syndrome.
- Because fluvoxamine strongly inhibits several liver enzymes (CYP1A2, CYP2C9, CYP2C19 and CYP3A4), it can raise blood levels of theophylline, warfarin, benzodiazepines, propranolol, methadone and clozapine, so doses of these may need adjusting.
- Combining with NSAIDs, aspirin or anticoagulants increases bleeding risk.
- Avoid alcohol, as it can worsen drowsiness.
- Tell your healthcare provider and pharmacist about every medicine and supplement you take before starting Luvox CR.
References
Frequently Asked Questions
Luvox (fluvoxamine), in the 150 mg extended-release capsule form known as Luvox CR, treats obsessive-compulsive disorder (OCD) in adults and children aged 8 and over, and social anxiety disorder in adults. It works as an SSRI, raising serotonin levels in the brain to ease repetitive thoughts, compulsions or anxiety.
Swallow Luvox CR capsules whole, once daily at bedtime, with or without food; do not crush, chew or open them. Your doctor usually starts you on 100 mg and may raise the dose by 50 mg a week, up to a maximum of 300 mg daily, depending on your response.
Common Luvox CR side effects include nausea, insomnia, drowsiness, dry mouth, sweating and sexual problems. Luvox carries an FDA boxed warning: it can increase suicidal thoughts and behaviour in children, teens and young adults, especially early in treatment. Get urgent help for agitation, high fever, severe muscle stiffness, or thoughts of self-harm.
Avoid monoamine oxidase inhibitors (MAOIs) entirely, and never combine Luvox with thioridazine, pimozide or tizanidine. Avoid alcohol and be cautious with other serotonin-raising drugs such as triptans, tramadol or St John's Wort, which raise the risk of serotonin syndrome. Fluvoxamine also raises blood levels of warfarin and some benzodiazepines.
If you miss a dose of Luvox CR, skip it and take your next capsule at the usual time the next day - do not double up. Never stop Luvox CR suddenly, since abruptly stopping can cause withdrawal symptoms such as anxiety, dizziness and irritability; your doctor will taper the dose gradually if needed.
Luvox CR is approved for OCD in children aged 8 and over, but not for social anxiety disorder in children. In pregnancy it is used only if the benefit outweighs the risk, since it may affect the newborn; discuss any pregnancy plans or breastfeeding with your healthcare provider before starting or stopping treatment.
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