TM Owner Bristol Myers Squibb
Platinol-AQ 100mg/100ml Vial
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Indications & Clinical Uses
- Platinol-AQ (cisplatin) is a platinum-based chemotherapy medicine, supplied as a ready-to-use 1 mg/mL solution rather than a powder for reconstitution, given by intravenous infusion in a hospital or oncology clinic under a physician experienced in cancer chemotherapy.
- In the US, cisplatin is approved, alone or combined with other chemotherapy, for advanced (metastatic) testicular cancer, advanced ovarian cancer, and advanced bladder cancer that has not responded to other treatment.
- Platinol-AQ and the original powder-based Platinol brand are the same active substance, cisplatin, at the same 1 mg/mL strength once Platinol is reconstituted - 'AQ' distinguished the pre-mixed aqueous solution from the original lyophilised powder.
- Both brand names have since been discontinued by Bristol-Myers Squibb in the US, and the current FDA label used here is for generic 'Cisplatin Injection.' Cisplatin carries an FDA boxed warning and must never be confused with the differently-dosed drug carboplatin.
Side Effects
- Platinol-AQ (cisplatin) carries an FDA boxed warning for four serious risks: kidney damage (nephrotoxicity) that can lead to acute kidney failure, nerve damage (peripheral neuropathy, usually dose-related and sometimes permanent), severe nausea and vomiting that requires preventive anti-sickness medicine before treatment, and bone marrow suppression that lowers infection-fighting white cells, platelets and red cells.
- Other very common effects include hearing changes or ringing in the ears (ototoxicity), especially in children, and temporary hair thinning.
- Serious reactions needing urgent medical attention include facial swelling, wheezing, a fast heartbeat or a sudden drop in blood pressure within minutes of the infusion (anaphylactic-type reaction), vision changes or loss, unusual bruising or bleeding, signs of infection such as fever, and a marked drop in urine output.
- Report ringing in the ears, tingling or numbness in the hands or feet, or breathlessness to the oncology team straight away.
Precautions & Warnings
- Platinol-AQ (cisplatin) must be given only as an intravenous infusion in a hospital or specialist cancer unit - it must never be given as a rapid injection, and equipment containing aluminium must be avoided because it reacts with cisplatin.
- Patients are given generous intravenous fluids before, during and for about 24 hours after each dose to protect the kidneys, and blood counts and kidney function (creatinine, blood urea) are checked before and repeatedly during treatment; the dose may be reduced or delayed if these are abnormal.
- Cisplatin must not be used in patients with pre-existing significant kidney impairment, hearing loss, bone marrow suppression, or a known severe hypersensitivity to cisplatin or other platinum compounds.
- It can seriously harm an unborn baby, so it is not used in pregnancy; women need effective contraception during treatment and for 14 months afterwards, and men for 11 months afterwards.
- Cisplatin can cause lasting infertility in both sexes, and breastfeeding is not recommended during treatment.
Avoid Interactions
- Combining Platinol-AQ (cisplatin) with other medicines that can damage the kidneys or hearing - such as aminoglycoside antibiotics, amphotericin B, loop diuretics like furosemide, or other nephrotoxic chemotherapy - increases the risk of kidney and ear damage, so these combinations are used only with careful monitoring.
- Cisplatin can lower blood levels of anticonvulsant medicines such as phenytoin, reducing seizure control; when combined with pyridoxine and altretamine, treatment response may be reduced.
- Live or live-attenuated vaccines should be avoided during and after cisplatin treatment because chemotherapy-related immune suppression can lead to serious infection from the vaccine itself.
- Cisplatin must never be prepared, diluted or given through equipment containing aluminium, as this causes a precipitate and reduces potency.
- Tell the oncology team about every other prescription and over-the-counter medicine, herbal product and vaccine before each cycle, as dose adjustments or extra monitoring may be needed.
References
Frequently Asked Questions
Platinol-AQ (cisplatin) is a ready-to-use chemotherapy solution used, alone or with other drugs, to treat advanced testicular cancer, advanced ovarian cancer, and advanced bladder cancer. It's given only in a hospital or cancer clinic under the care of a cancer specialist.
Platinol-AQ comes as a pre-mixed 1 mg/mL solution, given by slow intravenous infusion in a hospital, never a fast injection, typically once every 3 to 4 weeks per treatment cycle. You receive generous IV fluids before, during, and after each dose to protect your kidneys.
Platinol-AQ carries a boxed warning for kidney damage, nerve damage, severe nausea and vomiting, and reduced blood cell counts. Hearing loss and hair thinning are also common. Seek urgent care for facial swelling, wheezing, sudden low blood pressure, unusual bruising, fever, or passing very little urine.
Avoid other kidney- or hearing-damaging medicines, such as certain antibiotics and diuretics, and live vaccines, unless your cancer team approves them first. Platinol-AQ can seriously harm an unborn baby, so effective contraception is essential for both partners during treatment and for months afterward.
Before each cycle, your team checks kidney function, blood counts, hearing, and electrolytes such as magnesium. Because Platinol-AQ is infused over several hours, you're monitored closely throughout for allergic-type reactions - facial swelling, wheezing, or a sudden drop in blood pressure can occur within minutes of starting.
Yes - both contain the same active ingredient, cisplatin, at the same 1 mg/mL strength; Platinol-AQ is simply the ready-to-use liquid version, while the original Platinol was a powder mixed before use. Both brand names have since been discontinued in the US in favor of generic cisplatin injection.
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