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Uvadex 20mcg/mL Sterile Solution
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Indications & Clinical Uses
- UVADEX (methoxsalen) is a photosensitizing agent used for extracorporeal photopheresis, an apheresis procedure for treating cutaneous T-cell lymphoma (CTCL), mycosis fungoides, and Sézary syndrome that are unresponsive to other forms of treatment.
- The drug is administered intravenously and exposed to UVA light outside the body before blood is returned to the patient.
- This specialized procedure must be performed by experienced physicians with training in the THERAKOS CELLEX Photopheresis System.
- UVADEX provides palliative treatment of skin manifestations of CTCL.
Side Effects
- Hypotension from volume changes occurs in more than 1% of patients.
- Serious cardiovascular events including arrhythmias and infections have been reported.
- Other adverse reactions include nausea, photosensitivity reactions, fever, and hypersensitivity reactions including anaphylaxis.
- Serious events related to the photopheresis procedure itself can occur.
- Patients must wear UVA-absorbing wrap-around sunglasses and cover exposed skin for 24 hours after each treatment.
Precautions & Warnings
- UVADEX is contraindicated in patients with photosensitive diseases (lupus erythematosus, porphyria cutanea tarda, xeroderma pigmentosum, albinism), aphakia, or hypersensitivity to methoxsalen.
- Severe photosensitivity is a major concern: patients must strictly avoid sun exposure and use UVA-protective sunglasses for 24 hours post-treatment.
- Risk of premature skin aging and skin cancer increases with treatment.
- Cataract formation from UVA exposure is possible.
- Pregnancy may result in fetal harm.
Avoid Interactions
- UVADEX interacts with concomitant photosensitizing agents including anthralin, coal tar, griseofulvin, phenothiazines, sulfonamides, tetracyclines, and certain dyes.
- These agents increase photosensitivity reactions and should be avoided during treatment.
- Inform your physician of all medications, especially those that may increase sun sensitivity.
- Avoid herbal supplements like St. John's Wort that increase photosensitivity.
References
Frequently Asked Questions
Uvadex (methoxsalen) is used for photopheresis to treat cutaneous T-cell lymphoma that is unresponsive to other treatments. The drug is administered intravenously and exposed to UVA light outside the body before blood is returned to you. This specialized palliative treatment is performed only by trained physicians with experience using the THERAKOS CELLEX Photopheresis System.
Uvadex is given by intravenous administration as part of the photopheresis procedure using the THERAKOS CELLEX System. Your blood is treated outside your body with Uvadex and exposed to UVA light, then reinfused into you. Treatment frequency and duration depend on how your disease responds. Each session takes several hours.
Common side effects include low blood pressure and nausea. Serious cardiovascular events and infections have been reported in some patients. Severe photosensitivity reactions, fever, and allergic reactions including anaphylaxis can occur. Report chest pain, shortness of breath, fever, or unusual allergic symptoms to your healthcare provider immediately.
Patients with lupus, porphyria, xeroderma pigmentosum, or other photosensitive diseases cannot use Uvadex. After each treatment session, you must wear UVA-protective wrap-around sunglasses and cover all exposed skin for 24 hours. Long-term risks include skin cancer and cataract formation from UVA exposure. Pregnancy is contraindicated.
After photopheresis treatment, you must wear UVA-absorbing wrap-around sunglasses for the full 24 hours following treatment. Cover all exposed skin with protective clothing. Avoid direct sunlight completely. This is critical to prevent severe photosensitivity reactions and reduce long-term cumulative skin damage from repeated UV exposure during your treatment course.
Avoid photosensitizing medications like tetracyclines, sulfonamides, phenothiazines, anthralin, and coal tar during Uvadex treatment. Tell your doctor about all medications and supplements, especially those that increase sun sensitivity. Griseofulvin and certain dyes also increase photosensitivity. Herbal supplements like St. John's Wort should be avoided.
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