TM Owner Teva Pharmaceuticals
Doxycycline (Teva) 100 mg Capsule
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Indications & Clinical Uses
- Doxycycline (Teva) 100 mg capsules contain doxycycline, a broad-spectrum tetracycline antibiotic.
- It treats infections caused by susceptible organisms, including rickettsial infections such as Rocky Mountain spotted fever, Q fever and typhus; respiratory infections including Mycoplasma pneumoniae; chlamydia, urethritis, and gonorrhoea or syphilis when penicillin cannot be used; plague, tularaemia and cholera; acute intestinal amoebiasis as an adjunct; and severe acne as add-on therapy.
- It is also approved to prevent malaria caused by Plasmodium falciparum in short-term travellers (under 4 months) to areas with chloroquine or pyrimethamine-sulfadoxine resistance.
- The product sheet lists the category as antimalarial, but malaria prevention is only one of many approved uses and this is primarily an antibacterial.
- Capsules generally contain doxycycline hyclate while some tablets contain doxycycline monohydrate; both deliver an equivalent 100 mg of doxycycline.
- Teva supplies doxycycline in several markets.
Side Effects
- Doxycycline (Teva) has NO boxed warning.
- Nausea and vomiting are the commonest effects; diarrhoea, loss of appetite, indigestion and vaginal thrush occur less often.
- Photosensitivity - an exaggerated sunburn reaction on sun-exposed skin - is well recognised, and the capsules should be stopped at the first sign of skin redness.
- Rare but important reactions include oesophagitis and oesophageal ulceration, usually when a capsule is swallowed with too little water or just before lying down; Clostridioides difficile-associated diarrhoea, which can appear during or months after treatment; benign intracranial hypertension causing headache, blurred or double vision and, rarely, permanent visual loss; severe skin reactions including Stevens-Johnson syndrome and toxic epidermal necrolysis; hypersensitivity reactions up to anaphylaxis; and blood problems such as haemolytic anaemia and low platelets.
- Get urgent help for watery diarrhoea with fever, a spreading blistering rash, severe headache with visual change, or pain on swallowing.
Precautions & Warnings
- Doxycycline is contraindicated if you are allergic to tetracyclines, and the UK label also contraindicates it in pregnancy and in breastfeeding mothers.
- It is not given to children under 8 years (under 12 years on the UK label) except for severe or life-threatening infections such as rickettsial disease, because tetracyclines can permanently stain developing teeth and may slow bone growth.
- Swallow the capsule whole with a full glass of water while sitting or standing upright, and not immediately before going to bed, to prevent oesophageal ulceration; taking it with food reduces stomach upset without stopping it working.
- Use sunscreen and cover up, because sunburn happens more easily.
- People who are overweight or who have had intracranial hypertension are at higher risk of it recurring.
- Complete the full course even once you feel better.
- For malaria prevention, doxycycline does not replace repellent, nets and covering up.
- Store below 25 degrees C in the original container; the US label allows 20 to 25 degrees C.
Avoid Interactions
- Tell your provider and pharmacist about everything you take.
- Absorption of doxycycline is reduced by antacids containing aluminium, calcium or magnesium, by iron and zinc salts, by bismuth subsalicylate and by milk and dairy taken at the same time - separate these by 2 to 3 hours.
- Barbiturates, carbamazepine and phenytoin shorten doxycycline's half-life and lower its effect.
- Doxycycline increases the effect of warfarin and other anticoagulants, so the dose may need reducing and clotting monitored.
- It may reduce the reliability of combined oral contraceptives, so use an additional method during and just after the course.
- Avoid combining it with penicillins, whose bactericidal action is antagonised.
- Retinoids such as isotretinoin and acitretin must not be taken with doxycycline because of raised intracranial pressure.
- Ciclosporin levels may rise.
- Methoxyflurane anaesthesia with tetracyclines has caused fatal kidney toxicity - tell your anaesthetist.
References
Frequently Asked Questions
Doxycycline (Teva) 100 mg capsules treat bacterial infections including chest, urinary and sexually transmitted infections, rickettsial illnesses such as Q fever and typhus, and severe acne. Doxycycline is also taken once daily to prevent falciparum malaria in short-term travellers to chloroquine-resistant areas.
Swallow Doxycycline (Teva) capsules whole with a full glass of water, sitting or standing upright, and not right before bed. The usual adult dose is 200 mg on the first day, then 100 mg daily. Taking it with food reduces stomach upset without stopping it working.
Nausea and vomiting are the commonest side effects of Doxycycline (Teva). Doxycycline also makes skin burn far more easily in sunlight. Seek urgent help for watery diarrhoea with fever, painful swallowing, a spreading blistering rash, or severe headache with blurred vision. There is no boxed warning on this label.
Avoid taking antacids, iron, calcium, zinc, bismuth or dairy within 2 to 3 hours of your dose, as they block absorption. Avoid isotretinoin and other retinoids, and avoid penicillins. Avoid strong sunlight and sunbeds. Doxycycline can reduce the reliability of the contraceptive pill, so use extra protection.
For malaria prevention, take 100 mg of Doxycycline (Teva) once daily starting 1 to 2 days before you travel, every day while you are in the malarial area, and for 4 weeks after you leave. It does not replace insect repellent, nets and covering up.
Doxycycline (Teva) is not given to children under 8 years, or under 12 on the UK label, except for severe infections such as rickettsial disease where no alternative exists, because doxycycline can permanently stain developing teeth. The UK label also contraindicates it in pregnancy and breastfeeding.
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