TM Owner Validus Pharmaceuticals LLC (US label holder)
Lasix 40mg Tablet
Global Shipping : Reliable Global Distribution Network
Express Delivery : Priority Shipping for Every Order
Secure Payments : Trusted Payment Protection System
Disclaimer
Secure Handling
24/7 Worldwide Support
Global Access
Worldwide Access to Health
Cold-Chain Expert
Excellence in Cold-Chain
Trusted Supply
Certified Medical Supply
Indications & Clinical Uses
- Lasix 40 mg tablets contain furosemide, a potent loop diuretic or water tablet.
- They are used to treat oedema - fluid retention and swelling - associated with congestive heart failure, liver cirrhosis and kidney disease including the nephrotic syndrome, and to treat high blood pressure, usually when a thiazide diuretic alone is not enough.
- Furosemide acts on the loop of Henle in the kidney to remove salt and water quickly, and it still works when kidney function is reduced.
- The United States label opens with a prominent bolded warning that Lasix is a potent diuretic which, if given in excessive amounts, can lead to a profound diuresis with water and electrolyte depletion, so the dose is set individually and treatment is supervised with blood tests.
- The United States tablet label is held by Validus Pharmaceuticals; Sanofi remains the originator and the marketing authorisation holder in many other markets.
Side Effects
- Passing much more urine than usual in the hours after a dose is expected.
- Common effects include thirst, dry mouth, dizziness or light-headedness on standing, headache, blurred vision, constipation or diarrhoea and muscle cramps.
- The main risk is losing too much fluid and salt: low potassium, sodium, magnesium or calcium can cause weakness, cramps, palpitations, confusion or an irregular heartbeat, and dehydration can injure the kidneys.
- Ringing in the ears, hearing impairment and deafness have been reported, usually reversible, and are most likely with rapid intravenous injection, high doses, poor kidney function or other medicines that damage hearing.
- The tablet label has no formally boxed warning, but the bolded profound-diuresis warning must be taken seriously.
- Seek urgent help for a blistering rash, yellowing of the skin or eyes, fainting, or a marked fall in urine output.
Precautions & Warnings
- Lasix must not be used by anyone who is anuric (producing no urine) or who is allergic to furosemide, and it is used cautiously in people who have reacted to sulfonamide medicines.
- Blood tests for potassium, sodium, magnesium, calcium, kidney function and blood sugar are needed regularly, and more often in older people and in liver or heart failure.
- Stand up slowly, because Lasix lowers blood pressure and can cause falls, and tell your healthcare provider about gout, diabetes, lupus, an enlarged prostate or any history of hearing problems, as well as about pregnancy or breastfeeding.
- Furosemide given into a vein must be infused slowly, at no more than 4 mg per minute, to protect hearing.
- The 40 mg tablet, intravenous furosemide and the LASIX ONYU subcutaneous on-body infusor are different products with different doses and routes, and must never be swapped for one another.
Avoid Interactions
- Toxicity increases with aminoglycoside antibiotics such as gentamicin, and with ethacrynic acid or cisplatin, which add to the risk of hearing damage, and with lithium, whose blood levels rise dangerously.
- Corticosteroids increase potassium loss, and a low potassium level in turn makes digoxin toxicity and heart rhythm problems more likely.
- Blood pressure can fall sharply when Lasix is started alongside an ACE inhibitor or an angiotensin receptor blocker.
- Effectiveness is reduced by non-steroidal anti-inflammatory drugs such as ibuprofen and indometacin, which also raise the risk of kidney injury, and by sucralfate, which must be taken at least two hours apart from the dose.
- Chloral hydrate should be avoided.
- Alcohol adds to dizziness and dehydration.
- Tell your healthcare provider about every medicine and supplement, including over-the-counter painkillers.
References
Frequently Asked Questions
Lasix 40 mg (furosemide) is a loop diuretic that treats fluid retention and swelling caused by heart failure, liver cirrhosis and kidney disease, and also treats high blood pressure. It makes the kidneys remove extra salt and water, and usually starts working within an hour.
Lasix (furosemide) tablets are usually taken once or twice a day, with or without food, and the last dose is best taken early enough to avoid getting up at night to pass urine. Doses are adjusted gradually, because too much causes profound fluid and salt loss.
Passing much more urine is expected with Lasix (furosemide). Common side effects are thirst, dizziness on standing, headache, cramps and constipation. Losing too much salt and water can cause weakness, confusion or an irregular heartbeat. Ringing in the ears or hearing loss needs urgent medical attention.
Avoid anti-inflammatory painkillers such as ibuprofen with Lasix (furosemide), because they blunt its effect and can harm the kidneys. Lithium and aminoglycoside antibiotics such as gentamicin become more dangerous. Take sucralfate at least two hours apart. Alcohol adds to dizziness and dehydration.
Potassium, sodium, magnesium, calcium, kidney function and blood sugar are checked regularly while you take Lasix (furosemide), because it can strip out salts and fluid. Report cramps, palpitations, severe thirst or confusion. Store the tablets at 20°C to 25°C in a light-resistant container.
Take the missed Lasix (furosemide) dose as soon as you remember, unless your next dose is nearly due; then skip it and carry on as usual. Never take two doses together. If you remember late in the day, skipping avoids a disturbed night from passing urine.
Trusted & Reliable – Your Partner in Global Distribution.
We provide comprehensive lines of pharmaceutical products to support all your healthcare distribution needs.
