TM Owner Bristol Myers Squibb
Platinol 50mg/50ml Vial
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Indications & Clinical Uses
- Platinol (cisplatin) is a platinum-based chemotherapy medicine given by intravenous infusion in a hospital or oncology clinic, always under the supervision of a physician experienced in cancer chemotherapy.
- In the US, cisplatin is approved, alone or in combination with other chemotherapy, for advanced (metastatic) testicular cancer in men, advanced ovarian cancer, and advanced bladder cancer that has not responded to other treatment.
- The original brand name Platinol referred to a lyophilised powder for reconstitution to 1 mg/mL; the brand names Platinol and the later ready-to-use solution Platinol-AQ have both been discontinued by Bristol-Myers Squibb in the US, and cisplatin is now supplied mainly as generic 'Cisplatin Injection' at the same 1 mg/mL concentration - the current FDA label used for this product no longer displays a brand name.
- Cisplatin for injection carries an FDA boxed warning and must never be confused with the related, differently-dosed drug carboplatin.
Side Effects
- Cisplatin carries an FDA boxed warning for four serious risks: kidney damage (nephrotoxicity) that can lead to acute kidney failure, nerve damage (peripheral neuropathy, usually dose-related and sometimes permanent), severe nausea and vomiting that requires preventive anti-sickness medicine before treatment, and bone marrow suppression that lowers infection-fighting white cells, platelets and red cells.
- Other very common effects include hearing changes or ringing in the ears (ototoxicity), especially in children, and temporary hair thinning.
- Serious reactions needing urgent medical attention include facial swelling, wheezing, a fast heartbeat or a sudden drop in blood pressure within minutes of the infusion (anaphylactic-type reaction), vision changes or loss, unusual bruising or bleeding, signs of infection such as fever, and a marked drop in urine output.
- Report ringing in the ears, tingling or numbness in the hands or feet, or breathlessness to the oncology team straight away.
Precautions & Warnings
- Platinol (cisplatin) must be given only as an intravenous infusion in a hospital or specialist cancer unit - it must never be given as a rapid injection, and equipment containing aluminium must be avoided because it reacts with cisplatin.
- Patients are given generous intravenous fluids before, during and for about 24 hours after each dose to protect the kidneys, and blood counts and kidney function (creatinine, blood urea) are checked before and repeatedly during treatment; the dose may be reduced or delayed if these are abnormal.
- Cisplatin must not be used in patients with pre-existing significant kidney impairment, hearing loss, bone marrow suppression, or a known severe hypersensitivity to cisplatin or other platinum compounds.
- It can seriously harm an unborn baby, so it is not used in pregnancy; women need effective contraception during treatment and for 14 months afterwards, and men for 11 months afterwards.
- Cisplatin can cause lasting infertility in both sexes, and breastfeeding is not recommended during treatment.
Avoid Interactions
- Combining Platinol (cisplatin) with other medicines that can damage the kidneys or hearing - such as aminoglycoside antibiotics, amphotericin B, loop diuretics like furosemide, or other nephrotoxic chemotherapy - increases the risk of kidney and ear damage, so these combinations are used only with careful monitoring.
- Cisplatin can lower blood levels of anticonvulsant medicines such as phenytoin, reducing seizure control; when combined with pyridoxine and altretamine, treatment response may be reduced.
- Live or live-attenuated vaccines should be avoided during and after cisplatin treatment because chemotherapy-related immune suppression can lead to serious infection from the vaccine itself.
- Cisplatin must never be prepared, diluted or given through equipment containing aluminium, as this causes a precipitate and reduces potency.
- Tell the oncology team about every other prescription and over-the-counter medicine, herbal product and vaccine before each cycle, as dose adjustments or extra monitoring may be needed.
References
Frequently Asked Questions
Platinol (cisplatin) is a chemotherapy medicine used, alone or with other drugs, to treat advanced testicular cancer, advanced ovarian cancer, and advanced bladder cancer. It's given only in a hospital or cancer clinic, as part of a treatment plan managed by a cancer specialist.
Platinol is given as a slow intravenous infusion, never as a quick injection, usually once every 3 to 4 weeks per cycle. You'll receive extra IV fluids before, during, and after the infusion to protect your kidneys, and blood tests are done to check kidney function each cycle.
Platinol carries a boxed warning for kidney damage, nerve damage, severe nausea and vomiting, and lowered blood cell counts. Hearing changes and hair thinning are also common. Get urgent help for facial swelling, wheezing, sudden low blood pressure, unusual bleeding, fever, or a big drop in how much urine you pass.
Avoid other medicines that harm the kidneys or hearing, such as certain antibiotics and diuretics, and live vaccines, without discussing them with your cancer team first. Platinol can seriously harm an unborn baby, so effective contraception is essential during treatment and for months afterward.
Before each Platinol cycle, your care team checks kidney function (creatinine and blood tests), blood cell counts, hearing, and electrolytes like magnesium. Your dose may be reduced or delayed if results are abnormal, and you're watched closely during and after each IV infusion for reactions.
Yes - cisplatin, the active ingredient in Platinol, can cause lasting infertility in both men and women and can seriously harm a developing baby. Women need effective contraception during treatment and for 14 months after the last dose; men need it for 11 months after.
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