TM Owner Teva Pharmaceuticals
ProAir HFA 90mcg Inhaler
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Indications & Clinical Uses
- ProAir HFA 90 mcg is a pressurised metered-dose inhaler containing albuterol sulfate (also called salbutamol outside the US), a short-acting beta2-adrenergic agonist bronchodilator, made by Teva.
- It is approved in the US for the treatment or prevention of bronchospasm in patients 4 years of age and older with reversible obstructive airway disease such as asthma, and for prevention of exercise-induced bronchospasm in the same age group.
- Outside the US, salbutamol inhalers with equivalent active ingredient are widely marketed under brand names such as Ventolin and ProAir Digihaler (a breath-actuated powder version of the same drug, not interchangeable device-for-device with the HFA aerosol).
- ProAir HFA is a rescue (reliever) inhaler for as-needed use, not a controller medicine taken on a fixed daily schedule, and patients self-administer it.
Side Effects
- The most common reactions, occurring in clinical trials more often than with placebo, are headache, fast heartbeat, pain, dizziness, sore throat and a runny or stuffy nose.
- Overuse can cause tremor, nervousness, and low blood potassium.
- A serious but rare reaction is paradoxical bronchospasm, where breathing suddenly worsens immediately after use; stop the inhaler and seek urgent medical help if this happens.
- Needing the inhaler more often than usual, or needing more than one canister a month, signals that asthma is not well controlled and should be reviewed by a healthcare provider promptly, since excessive use of short-acting beta agonists has been linked to worsening asthma and, rarely, death.
- Chest pain, a very fast or irregular heartbeat, or severe shortness of breath after use needs emergency care.
Precautions & Warnings
- ProAir HFA should be used cautiously in people with heart disease, high blood pressure, an overactive thyroid, diabetes, or seizure disorders, since beta agonists can raise heart rate, blood pressure and blood sugar and lower blood potassium.
- It is for oral inhalation only and must not be swallowed or injected.
- The canister should be primed before first use and after two or more weeks without use, and the plastic actuator cleaned weekly to prevent blockage.
- Increasing reliance on ProAir HFA, or using it alongside a long-term asthma controller that stops working well, means the treatment plan needs review.
- There is no specific pregnancy contraindication stated, but use during pregnancy or breastfeeding should be discussed with a healthcare provider.
- It does not typically impair the ability to drive.
Avoid Interactions
- Tell your healthcare provider about all medicines you take.
- Other short-acting or long-acting beta-agonist bronchodilators should not be used at the same time as ProAir HFA except under medical advice, to avoid excessive cardiovascular stimulation.
- Beta-blockers, including eye drops used for glaucoma, can blunt the effect of ProAir HFA and may cause severe bronchospasm in people with asthma, so cardioselective beta-blockers are preferred if one must be used.
- Diuretics that lower potassium, such as loop or thiazide diuretics, can worsen albuterol-related low potassium and heart rhythm changes, and an ECG may be considered.
- Monoamine oxidase inhibitors, tricyclic antidepressants, and other sympathomimetic medicines can increase cardiovascular side effects when combined with ProAir HFA.
- Digoxin levels may fall slightly with albuterol use, so patients on digoxin should be monitored.
References
Frequently Asked Questions
ProAir HFA (albuterol sulfate) is a rescue inhaler that relieves and prevents bronchospasm in asthma and reversible airway disease in people 4 and older. It is also used just before exercise to prevent exercise-induced breathing problems. It is not a daily controller medicine.
Shake the inhaler and take 2 inhalations every 4 to 6 hours as needed for symptoms, or 2 inhalations 15 to 30 minutes before exercise. Prime it before first use and after 2 or more weeks unused, and rinse the mouth after use if desired.
Common ProAir HFA side effects include headache, fast heartbeat, dizziness, sore throat and nasal congestion. Rarely, it can cause paradoxical bronchospasm, where breathing suddenly worsens right after use; stop the inhaler and get urgent medical help immediately if this happens to you.
Avoid using other beta-agonist bronchodilators or beta-blocker medicines, including some glaucoma eye drops, without medical advice, since they interact with albuterol. Needing ProAir HFA more often than usual signals poorly controlled asthma and needs prompt review by a healthcare provider, not just repeat refills.
Store ProAir HFA between 15°C and 25°C (59°F to 77°F), away from heat above 49°C (120°F), which can make the canister burst. Wash the plastic actuator with warm water weekly and let it air dry fully before putting the canister back in.
Yes. ProAir HFA is approved for bronchospasm and exercise-induced bronchospasm in children 4 years of age and older, using the same 2-inhalation dosing as adults. Technique and spacer use should be checked regularly by a healthcare provider in younger children.
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