TM Owner Allergan / AbbVie
Trelstar Depot 3.75mg Vial
Global Shipping : Reliable Global Distribution Network
Express Delivery : Priority Shipping for Every Order
Secure Payments : Trusted Payment Protection System
Disclaimer
Secure Handling
24/7 Worldwide Support
Global Access
Worldwide Access to Health
Cold-Chain Expert
Excellence in Cold-Chain
Trusted Supply
Certified Medical Supply
Indications & Clinical Uses
- Trelstar Depot 3.75 mg is the once-monthly depot formulation of triptorelin pamoate, a gonadotropin-releasing hormone (GnRH) agonist, given as a single intramuscular injection into the buttock every 4 weeks.
- Although this sheet lists the brand as 'Trelstar Depot,' the current FDA label and DailyMed listing no longer use the 'Depot' or 'LA' suffixes - all three triptorelin pamoate strengths (3.75 mg monthly, 11.25 mg three-monthly, and 22.5 mg six-monthly) are now marketed simply as 'TRELSTAR' under one label; 'Trelstar Depot' was the original brand name for this 3.75 mg strength when first approved in 2000 and remains in wide clinical use.
- It is FDA-approved for the palliative treatment of advanced prostate cancer in adult men, initially raising then chronically suppressing testosterone to castrate levels, to slow hormone-sensitive prostate cancer growth.
- It is distributed in the US by Allergan USA (AbbVie) and manufactured by Debiopharm, Switzerland, and is given only by a healthcare professional in a clinic or hospital, never self-injected.
Side Effects
- Trelstar Depot has no boxed warning.
- Like all triptorelin pamoate doses, it first stimulates then suppresses testosterone, so symptoms can flare in the first weeks - watch for worsening bone pain, new numbness, weakness or difficulty passing urine, which need urgent review, especially in men with spinal metastases.
- Common effects include hot flushes, injection-site reactions, reduced libido, erectile dysfunction, testicular atrophy and fatigue.
- Because dosing is monthly, injection-site reactions and hot flushes are among the most frequently reported issues in practice.
- Long-term testosterone suppression can thin bones, cause anaemia and weight gain, alter mood, and affect heart rhythm (QT prolongation), raising cardiovascular and diabetes risk over repeated 4-weekly injections.
- Report chest pain, an irregular heartbeat, severe bone pain, or sudden loss of bladder control straight away.
Precautions & Warnings
- Trelstar Depot should be used with caution in men with vertebral metastases or urinary obstruction, due to the initial flare reaction, which can transiently worsen symptoms or, rarely, cause spinal cord compression in the first weeks after the first injection.
- It can prolong the QT interval, so caution is needed with heart-rhythm problems, electrolyte imbalance, or other QT-prolonging medicines.
- Monitor bone density, blood glucose and lipids during long-term monthly treatment.
- It is contraindicated in known hypersensitivity to GnRH agonists.
- Trelstar Depot is given only by intramuscular injection by a healthcare professional every 4 weeks - never intravenously - and is not for use in women or children.
- Because dosing is more frequent than the 3-monthly or 6-monthly Trelstar strengths, a delayed appointment should be rescheduled promptly with the clinic to keep testosterone suppressed.
- Store vials at 20°C to 25°C; do not freeze.
Avoid Interactions
- Avoid hyperprolactinaemic drugs, which can reduce pituitary GnRH receptor numbers and blunt Trelstar Depot's effect.
- Other QT-prolonging medicines - some antiarrhythmics, antibiotics and antipsychotics - add to the small QT-prolongation risk from testosterone suppression and need caution and monitoring when combined with monthly triptorelin dosing.
- No clinically significant food interaction is described.
- Do not mix Trelstar Depot with other injectable medicines in the same syringe.
- Tell your healthcare provider about every other medicine and supplement you take, particularly heart-rhythm medicines, before each monthly injection, so the clinic can decide whether extra ECG monitoring is needed during your course of treatment.
References
Frequently Asked Questions
Trelstar Depot 3.75 mg (triptorelin pamoate) is a monthly hormone-lowering injection for advanced prostate cancer. It works by suppressing testosterone to slow cancer growth. 'Depot' is the original brand name for this monthly strength; current labelling calls all Trelstar strengths simply 'Trelstar.'
A doctor or nurse gives Trelstar Depot as a single injection into the buttock muscle once every 4 weeks. You don't inject it yourself. Because it briefly raises testosterone first, symptoms can flare for the first couple of weeks before improving.
Common side effects of Trelstar Depot include hot flushes, injection-site reactions, low sex drive, erectile dysfunction and fatigue. Long-term monthly use can thin bones and affect heart rhythm. New bone pain, numbness or trouble passing urine in the first weeks needs urgent medical review.
Avoid drugs that raise prolactin, which can weaken Trelstar Depot's effect. Use caution with heart-rhythm medicines, since triptorelin can affect the QT interval. Trelstar Depot is for men only. Tell your care team about all your medicines before each monthly injection.
Yes - Trelstar Depot is the original name for the 3.75 mg, once-monthly strength of triptorelin pamoate. The current label drops 'Depot' and calls it simply Trelstar. The same brand also comes as an 11.25 mg (3-month) and 22.5 mg (6-month) injection for less frequent dosing.
Trelstar Depot is given by a clinician, not self-injected, so there's no home dose to manage - but delaying the monthly injection lets testosterone rise again, weakening cancer control. Contact the clinic promptly to reschedule if an appointment is missed or delayed.
Trusted & Reliable – Your Partner in Global Distribution.
We provide comprehensive lines of pharmaceutical products to support all your healthcare distribution needs.
