TM Owner Eli Lilly
Verzenio 150mg FC Tablet
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Indications & Clinical Uses
- Verzenio 150 mg tablets contain abemaciclib, a kinase (CDK4/6) inhibitor used in adults with hormone receptor-positive (HR+), HER2-negative breast cancer.
- In the US it is approved for adjuvant treatment, together with endocrine therapy, of node-positive early breast cancer at high risk of recurrence; for advanced or metastatic disease as initial endocrine-based therapy with an aromatase inhibitor; with fulvestrant after disease progression on endocrine therapy; and as a single agent in metastatic disease after prior endocrine therapy and chemotherapy.
- It is prescribed and supervised by a cancer specialist and taken at home.
- The same medicine is marketed as Verzenios in the EU and UK.
- The current US label (revised February 2025) is in use and no withdrawal or discontinuation was found.
- Verzenio tablets come in 50, 100, 150 and 200 mg strengths, which are used for dose adjustments.
Side Effects
- Very common reactions (20% or more of patients) are diarrhea, low white blood cell counts (neutropenia and leukopenia), nausea, abdominal pain, infections, tiredness, anemia, decreased appetite, vomiting, headache, hair loss and low platelets.
- Diarrhea affects roughly 81% to 90% of patients, usually within the first month, and can be severe.
- Serious reactions include severe neutropenia, lung inflammation (interstitial lung disease or pneumonitis, about 3%), liver problems (raised ALT and AST) and blood clots in veins or lungs (2% to 5%).
- Start anti-diarrheal medicine at the first sign of loose stools and drink plenty of fluids, and contact your care team promptly about fever, new cough or breathlessness, or leg swelling.
- There is no boxed warning.
Precautions & Warnings
- Blood counts are checked before treatment, every 2 weeks for the first 2 months, then monthly for 2 months and as clinically needed; liver tests follow the same schedule.
- Verzenio can cause fetal harm: women who can become pregnant should use effective contraception during treatment and for 3 weeks after the last dose and should not breastfeed during that time, and it may impair fertility in men.
- Severe hepatic impairment requires once-daily dosing, and use in severe renal impairment has not been studied.
- If you vomit or miss a dose, take the next dose at the usual time and do not take an extra dose.
- Swallow tablets whole; do not chew, crush or split them.
Avoid Interactions
- Increasing exposure or toxicity: avoid ketoconazole; with other strong CYP3A inhibitors (for example clarithromycin or itraconazole) the dose is reduced to 100 mg twice daily; moderate CYP3A inhibitors need monitoring and possible dose reduction; avoid grapefruit and grapefruit juice.
- Reducing effectiveness: avoid strong and moderate CYP3A inducers such as rifampin and carbamazepine.
- Tell your care team about every prescription and over-the-counter medicine, herbal product and supplement you take, and do not start or stop any of them without checking first, because starting or stopping a CYP3A inhibitor or inducer can change how much abemaciclib is in your body and your dose may need to be reviewed.
References
Frequently Asked Questions
Verzenio (abemaciclib) treats adults with hormone receptor-positive, HER2-negative breast cancer, either early stage at high risk of returning or advanced and metastatic. It is taken with hormone (endocrine) therapy, and alone in some metastatic cases after earlier treatment. Your cancer specialist decides which use applies to you.
Take Verzenio (abemaciclib) 150 mg by mouth twice a day, swallowing the tablets whole without chewing, crushing or splitting. If you vomit or miss a dose, take the next dose at the usual time and do not take an extra one.
The most common Verzenio side effects are diarrhea (about 8 to 9 in 10 people), low white blood cells, nausea, tiredness, infections and hair loss. Start anti-diarrheal medicine at the first loose stool. Call your care team for fever, new cough or breathlessness, or leg swelling.
Avoid grapefruit and grapefruit juice while taking Verzenio (abemaciclib). Also avoid ketoconazole and strong or moderate CYP3A inducers such as rifampin, and tell your care team about all other medicines, as some strong CYP3A inhibitors need a lower Verzenio dose.
Verzenio can lower white blood cells and affect the liver, so you need a blood count and liver tests before starting, every 2 weeks for the first 2 months, then monthly for 2 months and whenever needed. Your care team uses the results to decide whether to continue, pause or adjust treatment.
No. Verzenio (abemaciclib) can harm an unborn baby. Use effective contraception during treatment and for 3 weeks after the last dose, and do not breastfeed during that time. Verzenio may also reduce fertility in men. Tell your care team straight away if you think you may be pregnant.
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