TM Owner Gilead Sciences
Viread 300mg Tablet
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Indications & Clinical Uses
- Viread 300mg tablets contain tenofovir disoproxil fumarate (TDF), a nucleotide reverse transcriptase inhibitor antiviral.
- In the US, Viread is approved, with other antiretroviral medicines, for HIV-1 infection in adults and children aged 2 years and over weighing at least 10 kg, and on its own for chronic hepatitis B in adults and children aged 2 years and over weighing at least 10 kg.
- The usual dose of the 300 mg tablet is one tablet once daily, with or without food.
- Lower-strength tablets (150, 200 and 250 mg) and an oral powder (40 mg per gram) exist for children, so check the strength you have been given.
- Viread is not the same product as tenofovir alafenamide (TAF) medicines, which are a different form of tenofovir.
- Viread is made by Gilead Sciences.
Side Effects
- In people with HIV, the most common side effects (10% or more, grades 2 to 4) are rash, diarrhoea, nausea, headache, pain, depression and weakness (asthenia).
- In hepatitis B, nausea is the most common reaction in compensated disease.
- BOXED WARNING: severe acute worsening (exacerbation) of hepatitis B has been reported in people with hepatitis B who stop hepatitis B therapy, including Viread; liver function must be monitored closely after stopping.
- Other serious reactions include new or worsening kidney problems, loss of bone density with bone mineralisation defects, lactic acidosis with severe liver enlargement, and immune reconstitution syndrome.
- Do not stop Viread on your own, and report severe tiredness, muscle pain, stomach pain, yellow skin or eyes, or bone pain right away.
Precautions & Warnings
- Viread carries a boxed warning: hepatitis B can flare severely if treatment is stopped, so never stop it without medical advice.
- Kidney function should be monitored, as new or worsening renal impairment can occur.
- HIV antibody testing should be offered to all patients with hepatitis B before starting treatment.
- Bone density loss and lactic acidosis have been reported.
- Viread has no contraindications in the label.
- A pregnancy exposure registry monitors outcomes in exposed women.
- US guidance advises mothers with HIV not to breastfeed to avoid passing HIV to the baby.
- Store at 20°C to 25°C.
- Immune reconstitution syndrome can occur when starting HIV treatment.
Avoid Interactions
- Medicines that increase the effect or toxicity: didanosine (concentrations rise; close monitoring needed); drugs that harm the kidneys or compete for kidney elimination, including acyclovir, cidofovir, ganciclovir, valacyclovir, valganciclovir, aminoglycoside antibiotics and NSAIDs, which should be avoided or used with kidney monitoring; ledipasvir/sofosbuvir and other hepatitis C antivirals raise tenofovir levels, so watch for tenofovir side effects.
- Medicines that need adjustment: atazanavir must be given with ritonavir when taken with Viread, and some HIV protease inhibitors need extra tenofovir monitoring.
- The label lists no medicines that reduce Viread's efficacy.
- Tell your healthcare provider about all prescription medicines, over-the-counter medicines and supplements you take.
References
Frequently Asked Questions
Viread (tenofovir disoproxil fumarate) treats HIV-1 infection together with other HIV medicines, and chronic hepatitis B on its own. It is approved in adults and children aged 2 and over weighing at least 10 kg. The 300 mg tablet is one tablet once daily.
Take one Viread (tenofovir disoproxil fumarate) 300 mg tablet once daily, with or without food. Children who need lower doses use other strengths or the oral powder. Take it with other HIV medicines if you have HIV, and do not change your dose yourself.
Viread (tenofovir) most often causes rash, diarrhoea, nausea, headache, pain, depression and weakness. Serious effects include kidney problems, bone loss and lactic acidosis. The boxed warning is severe hepatitis B flares if you stop Viread, so never stop it without your healthcare provider's advice.
Avoid medicines that harm the kidneys while taking Viread (tenofovir), including acyclovir, ganciclovir, aminoglycoside antibiotics and NSAIDs. Didanosine and ledipasvir/sofosbuvir need close monitoring, and atazanavir must be taken with ritonavir. Do not stop Viread suddenly, because hepatitis B can flare.
On Viread (tenofovir disoproxil fumarate), your kidney function is monitored because kidney problems can occur. You should be offered HIV testing before hepatitis B treatment, and hepatitis B liver checks continue after you stop. Bone loss is also a known risk.
Stopping Viread (tenofovir disoproxil fumarate) can cause a severe flare of hepatitis B, which is its boxed warning. If you have hepatitis B, your liver function needs close monitoring after you stop. Talk to your healthcare provider before making any change.
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