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Zytiga 250mg Tablet
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Indications & Clinical Uses
- Zytiga 250 mg (abiraterone acetate) is an androgen biosynthesis (CYP17) inhibitor that lowers the male hormones that fuel prostate cancer.
- It is a cancer treatment, taken once daily by mouth together with a corticosteroid (prednisone or prednisolone).
- In the US it is approved for metastatic castration-resistant prostate cancer and for metastatic high-risk castration-sensitive prostate cancer.
- In the EU it is authorised for adult men with newly diagnosed high-risk metastatic hormone-sensitive prostate cancer (with androgen deprivation therapy), and for metastatic castration-resistant prostate cancer, both before chemotherapy and after docetaxel.
- The full 1,000 mg dose is four 250 mg tablets, taken as a single dose.
- Zytiga also comes as 500 mg film-coated tablets (two tablets make 1,000 mg), so check the strength on your pack.
Side Effects
- The most common reactions (at least 10%) in the US label are tiredness, joint pain, high blood pressure, nausea, swelling (oedema), low potassium, hot flushes, diarrhoea, vomiting, upper respiratory infection, cough and headache.
- In the EU, very common effects include peripheral oedema, low potassium, high blood pressure, urinary tract infections and raised liver enzymes.
- Serious effects include severe liver injury (fulminant hepatitis, acute liver failure and deaths have been reported), adrenal insufficiency, fluid retention, low blood sugar, and increased fractures when taken with radium-223.
- Zytiga has no boxed warning.
- Seek urgent help for yellow skin or eyes, dark urine, severe nausea or vomiting, weakness, dizziness, or chest pain, and report leg swelling or palpitations.
Precautions & Warnings
- Take Zytiga on an empty stomach as a single daily dose: do not eat for 2 hours before and 1 hour after taking it.
- Blood pressure and potassium need monthly monitoring, and liver function tests are required before and during treatment.
- Your team also watches for adrenal insufficiency and fluid retention.
- Take special care with heart disease, diabetes medicines and fluid retention.
- Zytiga can harm an unborn baby and is not for use in women; women who are or may become pregnant should not handle the tablets.
- Men with female partners who could become pregnant should use effective contraception during treatment and for 3 weeks after the last dose.
- Zytiga has no boxed warning.
Avoid Interactions
- Agents that increase the effect or toxicity: Zytiga blocks the enzyme CYP2D6, so dextromethorphan and thioridazine levels rise and dose reduction or avoidance is needed (in the EU also metoprolol and desipramine); it also raises pioglitazone exposure by about 46% (CYP2C8), and in the EU repaglinide.
- Diabetes medicines can increase the risk of low blood sugar, and combination with radium-223 increases fractures.
- Agents that reduce efficacy: strong CYP3A4 inducers such as rifampicin and phenytoin lower abiraterone levels and should be avoided, or the dose increased as your prescriber directs.
- Do not take Zytiga with food.
- Tell your healthcare provider about all prescription medicines, over-the-counter products and supplements you take.
References
Frequently Asked Questions
Zytiga (abiraterone acetate) treats prostate cancer that has spread. It is used with prednisone for metastatic castration-resistant prostate cancer and for high-risk metastatic hormone-sensitive (castration-sensitive) disease. It lowers the male hormones that help the cancer grow. It is not for use in women.
Take Zytiga (abiraterone acetate) as a single dose once daily on an empty stomach, with prednisone as prescribed. Do not eat for 2 hours before or 1 hour after. The usual 1,000 mg dose is four 250 mg tablets, taken at the same time each day.
Common Zytiga side effects include tiredness, joint pain, high blood pressure, swelling, low potassium, hot flushes, diarrhoea, nausea and cough. Serious effects include severe liver injury, adrenal insufficiency and low blood sugar. Report yellow skin or eyes, dark urine, or severe vomiting immediately.
Never take Zytiga (abiraterone acetate) with food; eat nothing for 2 hours before and 1 hour after. Avoid strong CYP3A4 inducers such as rifampicin and phenytoin. Dextromethorphan and thioridazine need dose adjustment, and combining with radium-223 raises fracture risk. Tell your prescriber about all medicines.
On Zytiga (abiraterone acetate), your blood pressure and potassium are checked monthly, and liver function tests are done before and during treatment because severe liver injury has occurred. Blood sugar may also need watching if you take diabetes medicines. Your care team sets the schedule.
No. Zytiga (abiraterone acetate) is not for use in women, can harm an unborn baby, and women who are or may become pregnant should not handle the tablets. Men with partners who could become pregnant should use effective contraception during treatment and for 3 weeks after the last dose.
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