Nicotrol NS 0.5mg Nasal Spray
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Indications & Clinical Uses
- Nicotrol NS (nicotine) Nasal Spray delivers about 0.5 mg of nicotine per spray, with one spray given in each nostril per dose, and is a prescription-only nicotine replacement therapy used as an aid to smoking cessation in adults who want to quit smoking.
- It relieves nicotine withdrawal symptoms and cravings more rapidly than other nicotine replacement forms because it is absorbed quickly through the nasal lining, which can make it more helpful for people with intense cravings.
- Nicotrol NS is intended for short-term use as part of a structured quit-smoking programme that includes behavioural support and counselling, and is approved for adults only.
- It is not intended for people who do not currently smoke, and treatment beyond 6 months is not recommended.
Side Effects
- The most common Nicotrol NS side effect is nasal and throat irritation - a runny nose, watering eyes, sneezing and a burning feeling in the nose or throat - reported by the great majority of users in the first days of use (very common) and easing with continued use.
- Headache, back pain, nausea and shortness of breath have also been reported.
- Because Nicotrol NS delivers nicotine quickly, it can lead to dependence on the spray itself in some users.
- Serious reactions that need urgent medical attention include a fast or irregular heartbeat, chest pain, severe dizziness, or signs of an allergic reaction such as facial swelling or difficulty breathing.
- Nicotine is poisonous to children and pets, so keep the bottle, even after use, safely out of reach.
Precautions & Warnings
- Nicotrol NS must not be used by anyone with a known allergy to nicotine or any component of the spray, and you should stop smoking completely before starting it.
- Each dose (one spray in each nostril) should not be repeated more than 5 times an hour, and total daily use should not exceed 40 mg (80 sprays); most people need at least 8 doses a day in the first weeks to control cravings.
- Use it with caution if you have heart disease, a recent heart attack, irregular heartbeat, high blood pressure, asthma or another reactive airway disease, or liver or kidney impairment, and discuss these conditions with your healthcare provider first.
- Nicotrol NS is not recommended during pregnancy, since animal studies show nicotine can cause fetal harm, and caution is needed while breastfeeding.
- Treatment is generally used for about 3 months and then tapered; total use beyond 6 months is not recommended.
- Keep the spray bottle, even once empty, safely away from children and pets.
Avoid Interactions
- Stopping smoking itself, whether or not you use Nicotrol NS, changes how your body processes certain medicines, including caffeine, acetaminophen, propranolol, insulin and theophylline, because tobacco smoke - not nicotine - affects liver enzymes and catecholamine levels; tell your healthcare provider you are stopping smoking so doses of these medicines can be reviewed.
- Using Nicotrol NS together with other nicotine-containing products, including cigarettes, patches, gum or e-cigarettes, can cause excessive nicotine exposure and should be avoided unless a healthcare provider directs otherwise.
- Tell your healthcare provider and pharmacist about every prescription medicine, over-the-counter drug and supplement you take before starting Nicotrol NS.
References
Frequently Asked Questions
Nicotrol NS (nicotine) Nasal Spray is a prescription stop-smoking aid that relieves nicotine withdrawal symptoms and cravings in adults quitting smoking. It delivers nicotine quickly through the nose, which can help with strong cravings. It works best alongside a behavioural support or counselling programme.
Spray one dose (one spray in each nostril) 1 to 2 times an hour as needed, up to 5 doses an hour and 40 mg (80 sprays) a day. Most people need at least 8 doses daily at first. Do not sniff, swallow or inhale through the nose while spraying.
Nicotrol NS commonly causes nasal irritation, a runny nose, watering eyes and sneezing, especially in the first few days, plus headache and nausea. Seek urgent help for a fast or irregular heartbeat, chest pain, or signs of an allergic reaction such as facial swelling.
Do not smoke while using Nicotrol NS, and avoid combining it with other nicotine products such as patches, gum or e-cigarettes unless your healthcare provider says otherwise. Keep the bottle, even once empty, away from children and pets, since swallowed nicotine can be dangerous.
Nicotrol NS is usually used for about 3 months and then the dose is gradually tapered down. The label does not recommend using it for longer than 6 months in total. Talk to your healthcare provider if you feel you still need it after this time.
Nicotrol NS is not recommended during pregnancy, since animal studies show nicotine can cause fetal harm; discuss behavioural support options with your healthcare provider first. Caution is also needed while breastfeeding, because nicotine passes into breast milk.

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