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Quadracel 0.5mL Injection
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Indications & Clinical Uses
- Quadracel is a diphtheria and tetanus toxoids and acellular pertussis adsorbed and inactivated poliovirus (DTaP-IPV) vaccine supplied as a single 0.5 mL dose for intramuscular injection, manufactured by Sanofi Pasteur Limited in Toronto, Canada and distributed in the US by Sanofi Pasteur Inc.
- It is FDA-approved for active immunisation of children 4 through 6 years of age, given as the fifth dose of the DTaP series and the fourth or fifth dose of the IPV series, in children whose earlier doses used Pentacel, Daptacel and/or Vaxelis vaccines.
- Quadracel is given only by a healthcare professional in a clinic or pharmacy setting -- it is never self-administered and there is no dose to remember at home.
- It is not interchangeable with other manufacturers' DTaP-IPV products for completing the same series unless the original product is unavailable.
Side Effects
- Injection-site reactions are very common: pain in more than 3 in 4 children, swelling in more than 2 in 3, and redness in more than half.
- Systemic reactions are also common, including muscle aches in more than half, tiredness in more than 1 in 3, and headache in more than 1 in 6; fever is less frequent.
- Quadracel's label carries no boxed warning.
- Rare but serious reactions include severe allergic reaction (anaphylaxis), which is why children are usually observed for 15 minutes after vaccination, and fainting (syncope), which can happen after any injection, particularly in older children and adolescents.
- Seek urgent medical attention for difficulty breathing, facial or throat swelling, hives, a high fever, unusual drowsiness, or a seizure following vaccination.
Precautions & Warnings
- Quadracel must not be given to a child who has had a severe allergic reaction to a previous dose or to any vaccine component, or who developed encephalopathy within 7 days of an earlier pertussis-containing vaccine.
- Vaccination should be postponed, not skipped, during moderate or severe acute illness, but can proceed with a mild illness such as a cold.
- Use caution in children with a history of Guillain-Barre syndrome or a progressive neurological disorder, which should be stabilised before immunisation.
- Quadracel should be stored at 2 to 8C and never frozen; a vaccine that has been frozen must be discarded.
- Tell the vaccinator about any bleeding disorder, as intramuscular injection requires care in these children, and about any immune-suppressing condition or treatment, which may reduce the vaccine's effectiveness.
Avoid Interactions
- Quadracel can be given at the same visit as other routine childhood vaccines, such as MMR, varicella or influenza vaccine, but each vaccine must be given with a separate syringe at a different injection site.
- Children receiving immunosuppressive therapy (such as high-dose corticosteroids, chemotherapy or radiation) or who have an immunodeficiency may have a reduced immune response to Quadracel, and vaccination timing should be discussed with the healthcare provider.
- There are no known drug interactions requiring dose adjustment, but tell the vaccinator about all medicines, supplements and any recent or planned vaccinations, and about any allergic reaction to a previous vaccine.
References
Frequently Asked Questions
Quadracel is a combination vaccine that protects children aged 4 through 6 against diphtheria, tetanus, whooping cough (pertussis) and polio. It is given as the fifth DTaP dose and fourth or fifth IPV dose, completing the childhood immunisation series started with earlier Sanofi Pasteur vaccines.
Quadracel is a single 0.5 mL injection given into the muscle, usually the upper arm, by a doctor or nurse at a clinic visit. It is given only once as part of the routine schedule at 4 to 6 years old, not at home, and needs no repeat dosing that visit.
Most children get pain, swelling or redness where Quadracel is injected, and many have muscle aches, tiredness or headache afterward. These are usually mild and pass within a few days. Seek urgent care for facial swelling, hives, breathing trouble, a seizure or a very high fever.
Tell the vaccinator about any severe allergic reaction to a previous dose or vaccine ingredient, encephalopathy after an earlier pertussis vaccine, or a history of Guillain-Barre syndrome. Vaccination is delayed, not skipped, if your child has a moderate or severe illness on the day.
A nurse or doctor gives the single injection and typically asks you to wait about 15 minutes to watch for a rare allergic reaction. Quadracel can be given at the same visit as other scheduled vaccines, each in a separate syringe at a different injection site.
No. Quadracel is approved specifically for the fifth DTaP and fourth or fifth IPV dose in children aged 4 through 6 years. Younger children use other Sanofi Pasteur vaccines such as Pentacel or Daptacel, and older children and adults need different formulations.
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