TM Owner Allergan / AbbVie
Sanctura 20mg Tablet
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Indications & Clinical Uses
- Sanctura 20 mg (trospium chloride) is an antimuscarinic (anticholinergic) tablet used to treat overactive bladder in adults, reducing symptoms of urinary urgency, frequency and urge incontinence (leaking urine with a sudden strong need to go) by relaxing the bladder muscle.
- Sanctura is the immediate-release formulation, taken twice daily; it should not be confused with the once-daily extended-release capsule Sanctura XR, which delivers a different dose profile and is not interchangeable milligram-for-milligram without medical guidance.
- Trospium is also available as a generic tablet from other manufacturers under the same chemical name.
- Sanctura is intended for use only in adults with overactive bladder; it is not indicated for other causes of urinary frequency, and any new or worsening urinary symptoms should first be evaluated by a healthcare provider to rule out other causes such as infection.
Side Effects
- Sanctura has no boxed warning.
- The most common reaction, reported in about 1 in 5 people, is dry mouth; constipation (about 1 in 10) and headache are also common, reflecting trospium's anticholinergic action throughout the body.
- Sanctura can also cause blurred vision, dizziness and drowsiness.
- A rare but serious reaction is angioedema, a sudden swelling of the face, lips, tongue or throat that can affect breathing; stop Sanctura and get emergency medical help immediately if this occurs.
- Because trospium can slow bowel movement, tell your healthcare provider if constipation becomes severe, or you develop stomach pain and bloating, which could signal reduced gut motility.
- People aged 75 or older may be more sensitive to anticholinergic side effects such as confusion or drowsiness.
Precautions & Warnings
- Sanctura must not be used in urinary retention, gastric retention (delayed stomach emptying), uncontrolled narrow-angle glaucoma, or known hypersensitivity to trospium.
- Use with caution in bladder outflow obstruction, since urinary retention risk increases, and in conditions that slow gut movement, such as ulcerative colitis or intestinal blockage.
- Sanctura can cause drowsiness or blurred vision, so avoid driving or operating machinery until you know how it affects you.
- Dose adjustment is recommended in moderate to severe kidney impairment because anticholinergic side effects are more pronounced, and older adults, particularly those 75 and over, should be monitored closely for confusion, dizziness or falls.
- Take Sanctura on an empty stomach, at least one hour before food, since food reduces its absorption.
- Discuss use in pregnancy and breastfeeding with your healthcare provider.
Avoid Interactions
- Taking Sanctura with other anticholinergic (antimuscarinic) medicines, such as certain antihistamines, medicines for depression, or other overactive bladder drugs, can add to side effects like dry mouth, constipation, blurred vision and confusion, so combinations should be reviewed by a healthcare provider.
- Metformin can reduce the amount of trospium absorbed by roughly 30 percent, potentially affecting its bladder-control effect.
- Trospium is mainly cleared by the kidneys through tubular secretion, so other medicines eliminated the same way could compete for this pathway, though no clinically significant interaction with digoxin has been shown.
- Take Sanctura on an empty stomach, since food reduces absorption.
- Tell your healthcare provider and pharmacist about all prescription and over-the-counter medicines and supplements you take before starting Sanctura.
References
Frequently Asked Questions
Sanctura (trospium chloride) 20 mg tablets treat overactive bladder in adults, easing urinary urgency, frequency and urge incontinence by relaxing the bladder muscle. It's the immediate-release, twice-daily form of trospium, different from the once-daily Sanctura XR capsule.
Take one 20 mg tablet twice daily on an empty stomach, at least one hour before a meal, since food reduces how much trospium your body absorbs. Swallow the tablet whole with water; don't crush or chew it.
Dry mouth is the most common effect, affecting about 1 in 5 people, followed by constipation and headache. Sanctura can also cause blurred vision or drowsiness. Get emergency help immediately for sudden swelling of the face, lips, tongue or throat, a rare sign of angioedema.
Avoid driving until you know how Sanctura affects you, since it can cause drowsiness or blurred vision. Combining it with other anticholinergic medicines, like some antihistamines or antidepressants, can worsen dry mouth and constipation. Tell your healthcare provider about every medicine you take.
Skip the missed dose if it's almost time for your next one, and don't double up; otherwise take it on an empty stomach as soon as you remember. Store Sanctura at 20°C to 25°C, and space doses about 12 hours apart for the best effect.
Yes, but people aged 75 and over may be more sensitive to side effects such as confusion, dizziness or drowsiness, and dose adjustment may be needed with reduced kidney function. Tell your healthcare provider your age and kidney health before starting Sanctura.
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