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Zoloft 100mg Tablet
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Indications & Clinical Uses
- Zoloft 100 mg is a film-coated tablet containing sertraline hydrochloride, a selective serotonin reuptake inhibitor (SSRI) antidepressant.
- In the US it is approved for major depressive disorder, panic disorder, posttraumatic stress disorder, social anxiety disorder and premenstrual dysphoric disorder in adults, and for obsessive-compulsive disorder in adults and in children aged 6 years and older.
- Safety and effectiveness have not been established in children for other uses.
- Zoloft tablets come in 25 mg, 50 mg and 100 mg strengths, and a separate Zoloft oral solution (20 mg/mL, which contains alcohol) also exists, so check the form and strength before use.
- It is taken by mouth at home under a prescriber's direction.
- This information comes from the current US label (Viatris Specialty LLC, previously Pfizer).
Side Effects
- BOXED WARNING: antidepressants, including Zoloft, increased the risk of suicidal thoughts and behaviour in children, adolescents and young adults in short-term studies, so everyone starting treatment should be closely monitored for clinical worsening and new suicidal thoughts.
- Common side effects (at least 5% and twice placebo) include nausea (26%), diarrhoea or loose stools (20%), insomnia (20%), dry mouth (14%), tiredness (12%), dizziness (12%), sleepiness (11%), tremor (9%), indigestion, agitation, sweating, reduced appetite, reduced sex drive and ejaculation failure.
- Serious reactions include serotonin syndrome, abnormal bleeding, low sodium levels, angle-closure glaucoma and withdrawal-type symptoms if the medicine is stopped abruptly.
- Contact your doctor at once for suicidal thoughts, severe agitation, fever with muscle stiffness or unusual bleeding.
Precautions & Warnings
- Zoloft is contraindicated with monoamine oxidase inhibitors (or within 14 days of stopping one), with pimozide, and in known hypersensitivity to sertraline; the oral solution is also contraindicated with disulfiram.
- All patients should be monitored for clinical worsening and suicidality, especially early in treatment and after dose changes, and screened for bipolar disorder before starting.
- Do not stop suddenly: discontinuation symptoms such as nausea, sweating, irritability, agitation and dizziness can occur.
- Use in late pregnancy may raise the risk of persistent pulmonary hypertension and withdrawal symptoms in the newborn, and SSRI exposure near delivery is linked with a small increase in postpartum haemorrhage, so discuss pregnancy plans with your doctor.
- Avoid use with untreated narrow-angle anatomy of the eye.
- Zoloft may cause drowsiness, so take care driving until you know how it affects you.
- Alcohol is not recommended.
- Store tablets at 20°C to 25°C.
Avoid Interactions
- Increase effect or toxicity: never take Zoloft with monoamine oxidase inhibitors, pimozide or, for the oral solution, disulfiram.
- Other serotonergic medicines such as buspirone, fentanyl, linezolid, lithium, methylene blue, tryptophan, tramadol, triptans and St John's wort can cause serotonin syndrome.
- NSAIDs (aspirin, ibuprofen, naproxen), other antiplatelet drugs and warfarin raise the risk of bleeding.
- Zoloft may affect medicines broken down by CYP2D6, whose doses may need reducing, and phenytoin levels should be monitored.
- It can interact with highly protein-bound drugs and with cimetidine.
- Alcohol is not recommended.
- Reduce efficacy: the label highlights list no specific medicine that clearly reduces the effect of Zoloft.
- Tell your prescriber about all medicines and supplements you use.
References
Frequently Asked Questions
Zoloft (sertraline) is an SSRI antidepressant used in adults for major depression, panic disorder, PTSD, social anxiety disorder and premenstrual dysphoric disorder. It is also used for obsessive-compulsive disorder in adults and in children aged 6 and over. Its safety in children is not established for other conditions.
Take Zoloft (sertraline) tablets by mouth once daily, in the morning or evening, at about the same time each day. Your doctor sets the dose; tablets come in 25, 50 and 100 mg. Do not stop suddenly, because nausea, dizziness, irritability and other withdrawal-type symptoms can occur.
The most common Zoloft side effects are nausea, diarrhoea, insomnia, dry mouth, tiredness, dizziness, sleepiness and tremor, plus sexual side effects. Serious ones include serotonin syndrome, unusual bleeding and low sodium. Contact your doctor immediately for suicidal thoughts, severe agitation, muscle stiffness with fever or bleeding.
Never take Zoloft with an MAO inhibitor (or within 14 days of stopping one) or with pimozide. Avoid other serotonin-raising drugs such as tramadol, triptans, linezolid and St John's wort unless your doctor agrees. NSAIDs and warfarin raise bleeding risk. Alcohol is not recommended with sertraline.
If you miss a Zoloft dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed one and go back to your normal schedule. Never take a double dose to make up for a missed one.
Yes. Zoloft carries a boxed warning: antidepressants, including sertraline, raised the risk of suicidal thoughts and behaviour in children, adolescents and young adults. Anyone starting Zoloft should be closely watched for worsening mood. Contact your doctor immediately if suicidal thoughts appear, especially early in treatment or after a dose change.
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